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In 1992 in El Paso, TX a randomized, double-blind, placebo controlled study of subjects (n=130) with allergic rhinitis in 1992-1993 was conducted. The average IgE level of the placebo treated subjects remained essentially flat, while the average IgE multi vitamin level for active treated subjects was reduced vitamin significantly from baseline to day 30.7 in 1993 in el paso, tx, valid subjects (n=66) returned a second set of symptom diaries which they had completed for days 365 multi to 395 (the same period, one year after the first set vitamin of symptom diaries). the active group had mean symptom scores showing statistically significant decreases from 1992 to 1993. the placebo group had increased symptoms in multi and vitamin 1993. (the relevant pollen counts at the study site in 1993 were much higher than in 1992, leading to expectation of higher symptoms.)7

studies indicate that ingested oral cyanocobalamin tablets are ineffective in the treatment of allergic multi disease, perhaps because once ingested, they are directly metabolized in the liver. when b12 is delivered via injection or lozenge it passes throughout the bloodstream before arriving at the liver. it is during this first pass in its native form that it is believed to exert its therapeutic effect. clinical research: "the world vitamin health organization (who) recognizes allergic rhinitis (hay fever), multi sinusitis, vitamin and multi asthma,...conjunctivitis, vitamin urticaria, eczema, dermatitis (contact and atopic)...allergic and migraine headache...as diseases in which ige-mediated allergy may be involved."1 in 1988, asthma and allergic rhinitis subjects were treated with b12. total ige, specific ige and pulmonary lung functions were taken at days 45, 150 and 180 from baseline. eight of the 9 subjects multi had reduced ige. 2 in 1989 open label studies at two sites in riverside county, ca in 1989. sixteen of the 17 subjects had lowered ige levels from day vitamin 0 to day multi 30.3

with no further treatment, the 1996 ten-month vitamin follow-up data (n=92) from multi a high pollen period in oregon, washington vitamin and idaho together showed a greater reduction in multi the active group (n=43) than the placebo group (n=49) on the primary endpoint, defined as a combination of symptom and rescue medication scores.8 patients gave blood serum samples prior to the treatment in 1995 and one year later in 1996. they were immunoassayed for specific ige antibodies using a chemi-luminescent technique. statistician bradley rosebrook ran t-tests comparing average baseline ige levels to one-year. for the seasonal allergens vitamin reported, the active group (n=27) had on average a greater reduction in ige than the placebo group (n=34) for 13 out of 16 allergens.8